Article
Membrane pore formation by pentraxin proteins from Limulus, the American horseshoe crab.
The Biochemical journal - 15 Jul 2008
Harrington John M, Chou Hui-Ting, Gutsmann Thomas, Gelhaus Christoph, Stahlberg Henning, Leippe Matthias, Armstrong Peter B
Abstract excerpt
The pentraxins are a family of highly conserved plasma proteins of metazoans known to function in immune defence. The canonical members, C-reactive protein and serum amyloid P component, have been identified in arthropods and humans. Mammalian pentraxins are known to bind lipid bilayers, and a pentraxin representative from the American horseshoe crab, Limulus polyphemus, binds and permeabilizes mammalian...
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