Article

Phage-encoded cationic antimicrobial peptide used for outer membrane disruption in lysis

2019-01-08

Abstract excerpt

Spanins are required for the last step in bacteriophage lysis: the disruption of the outer membrane. Bioinformatic analysis has shown that ~15% of phages lack a spanin gene, which suggests an alternate mechanism of outer membrane disruption. To address this, we selected virulent podophage ϕKT as a spaninless exemplar and tested ϕKT genes for outer membrane disruption during lysis. Hypothetical novel gene 28 cause...

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Literature Corpus work: 1403b712-6b1d-5863-bd3e-2b465579fc03
DOI: 10.1101/515445

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