Article
A process for controlling intracellular bacterial infections induced by membrane injury.
Science (New York, N.Y.) - 4 Jun 2004
Roy Deepannita, Liston David R, Idone Vincent J, Di Anke, Nelson Deborah J, Pujol Céline, Bliska James B, Chakrabarti Sabyasachi, Andrews Norma W
Abstract excerpt
Strategies for inhibiting phagolysosome fusion are essential for the intracellular survival and replication of many pathogens. We found that the lysosomal synaptotagmin Syt VII is required for a mechanism that promotes phagolysosomal fusion and limits the intracellular growth of pathogenic bacteria. Syt VII was required for a form of Ca2+-dependent phagolysosome fusion that is analogous to Ca2+-regulated...
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