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Article

Modulation of mutant huntingtin N-terminal cleavage and its effect on aggregation and cell death.

Neurotoxicity research - 1 Aug 2011

Juenemann Katrin, Weisse Christina, Reichmann Denise, Kaether Christoph, Calkhoven Cornelis F, Schilling Gabriele

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disorder caused by a polyglutamine expansion near the N-terminus of huntingtin. A neuropathological hallmark of Huntington's disease is the presence of intracellular aggregates composed of mutant huntingtin N-terminal fragments in human postmortem...

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Identifiers

PMID: 21116768
DOI: 10.1007/s12640-010-9227-6
PMCID: PMC3110280

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21116768-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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