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Article

Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Feb 1999

Kim M, Lee H S, LaForet G, McIntyre C, Martin E J, Chang P, Kim T W, Williams M, Reddy P H, Tagle D, Boyce F M, Won L, Heller A, Aronin N, DiFiglia M

Abstract excerpt

Neuronal intranuclear inclusions are found in the brains of patients with Huntington's disease and form from the polyglutamine-expanded N-terminal region of mutant huntingtin. To explore the properties of inclusions and their involvement in cell death, mouse clonal striatal cells were transiently transfected with truncated and full-length human wild-type and mutant huntingtin cDNAs. Both normal and mutant...

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PMID: 9920660
PMCID: PMC6782141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition.PMID 9920660Read ↗

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