Article
Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Feb 1999
Kim M, Lee H S, LaForet G, McIntyre C, Martin E J, Chang P, Kim T W, Williams M, Reddy P H, Tagle D, Boyce F M, Won L, Heller A, Aronin N, DiFiglia M
Abstract excerpt
Neuronal intranuclear inclusions are found in the brains of patients with Huntington's disease and form from the polyglutamine-expanded N-terminal region of mutant huntingtin. To explore the properties of inclusions and their involvement in cell death, mouse clonal striatal cells were transiently...
Topics
- Amino Acid Chloromethyl Ketones
- Animals
- Apoptosis
- Blotting, Western
- Caspase Inhibitors
- Cell Survival
- Clone Cells
- Corpus Striatum
- Cysteine Proteinase Inhibitors
- Humans
- Huntingtin Protein
- Inclusion Bodies
- Mice