Article
Expression of c-kit, a proto-oncogene of the murine W locus, in cerebella of normal and neurological mutant mice: immunohistochemical and in situ hybridization analysis.
Differentiation; research in biological diversity - 1 Oct 1992
Takeda H, Yoshiki A, Nishikawa S, Nishikawa S, Kunisada T, Sakakura T, Amanuma H, Kusakabe M
Abstract excerpt
The c-kit proto-oncogene encodes a receptor tyrosine kinase and is allelic with the murine white-spoting (W) locus. Although no apparent defects in the brain have been reported in W mutant mice, brain tissue, especially cerebellum, shows a high level of c-kit transcription. In the present study,...
Topics
- Alleles
- Animals
- Blotting, Northern
- Cerebellum
- Gene Expression Regulation, Neoplastic
- Immunohistochemistry
- In Situ Hybridization
- Intermediate Filaments
- Mice
- Mice, Inbred C57BL
- Mice, Neurologic Mutants
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-kit