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Article

Helicobacter pylori infection is an independent risk factor for Runx3 methylation in gastric cancer

1 Jan 2008

Abstract excerpt

Runx3, a member of the human runt-related transcription factor family, is known as a possible tumor suppressor gene for gastric cancer. Runx 3 expression is frequently suppressed by the promoter hypermethylation in gastric cancer cell lines and tissues. However, the precise mechanism of the induction of Runx3 methylation, which is considered to be a critical step in gastric carcinogenesis, remains to be...

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PMID: 18097595
DOI: 10.3892/or.19.1.197

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