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Article

Increased genetic susceptibility to intestinal-type gastric cancer is associated with increased activity of the RUNX3 distal promoter.

Cancer - 15 Nov 2011

Lim Byungho, Ju Hyoungseok, Kim Minjin, Kang Changwon

Abstract excerpt

BACKGROUND: The runt-related transcription factor RUNX3 plays essential roles in various types of tumors, including gastric cancer. Epigenetic changes in the methylation of the RUNX3 proximal promoter, but not common genetic changes in RUNX3, have been associated with both changes in the gene expression and development of the cancer. METHODS: A case-control association study was conducted by genotyping 865...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21523770
DOI: 10.1002/cncr.26161

Genes

RUNX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

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Increased genetic susceptibility to intestinal-type gastric cancer is associated with increased activity of the RUNX3 distal promoter.PMID 21523770Read ↗

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Helicobacter pylori infection is an independent risk factor for Runx3 methylation in gastric cancerSemantic proximity Read ↗

Molecular pathology of RUNX3 in human carcinogenesis.Semantic proximity Read ↗

A functional polymorphism within the distal promoter of RUNX3 confers risk of colorectal cancer.Semantic proximity Read ↗

Significant association of RUNX3 T/A polymorphism at intron 3 (rs760805) with the risk of gastric atrophy in Helicobacter pylori seropositive Japanese.Semantic proximity Read ↗

Association of Promoter Methylation of RUNX3 Gene with the Development of Esophageal Cancer: A Meta AnalysisSemantic proximity Read ↗

Remote modulation of lncRNA GCLET by risk variant at 16p13 underlying genetic susceptibility to gastric cancer.Semantic proximity Read ↗

IκBα polymorphisms were associated with increased risk of gastric cancer in a southern Chinese population: a case-control study.Semantic proximity Read ↗

A novel functional TagSNP Rs7560488 in the DNMT3A1 promoter is associated with susceptibility to gastric cancer by modulating promoter activity.Semantic proximity Read ↗

Chromatin immunoprecipitation and association study revealed a possible role of Runt-related transcription factor 3 in the ulcerative colitis of Chinese population.Semantic proximity Read ↗

IkappaBalpha polymorphism at promoter region (rs2233408) influences the susceptibility of gastric cancer in Chinese.Semantic proximity Read ↗

An inverse relationship between the expression of the gastric tumor suppressor RUNX3 and infection with Helicobacter pylori in gastric epithelial dysplasia.Semantic proximity Read ↗

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