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Article

Expression of RUNX3 Gene, Methylation Status and Clinicopathological Significance in Breast Cancer and Breast Cancer Cell Lines

1 Jan 2008

Abstract excerpt

BACKGROUND: Runt-related transcription factor 3 (RUNX3) is a novel tumor suppressor gene that is frequently silenced by promoter hypermethylation in gastric cancer. In this study, we aimed to analyze the methylation status of the RUNX3 promoter in breast cancer and to evaluate the relationship between RUNX3 expression and breast carcinogenesis and prognosis. METHODS: RT-PCR and Western blot were applied on 5...

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PMID: 18580070
DOI: 10.1159/000132385

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