Article
Mitochondrial resequencing arrays detect tumor-specific mutations in salivary rinses of patients with head and neck cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2007
Mithani Suhail K, Smith Ian M, Zhou Shaoyu, Gray Andrew, Koch Wayne M, Maitra Anirban, Califano Joseph A
Abstract excerpt
PURPOSE: Alterations of the mitochondrial genome have been identified in multiple solid tumors and in many head and neck squamous cell carcinomas (HNSCC). Identification of mitochondrial mutations in the salivary rinses of patients with HNSCC has potential application in disease detection. In this study, we used the MitoChip v2.0 mitochondrial genome resequencing array to detect minor populations of mitochondrial...
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