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Increased Mitochondrial DNA Content in Saliva Associated with Head and Neck Cancer

1 Apr 2005

Abstract excerpt

Alterations of the mitochondrial DNA (mtDNA) have been described in human tumors and in other tissues in association with smoking exposure. We did quantitative PCR of cytochrome c oxidase I (Cox I) and cytochrome c oxidase II (Cox II) genes on oral rinse samples obtained from 94 patients with primary head and neck squamous cell carcinoma (HNSC) and a control group of 656 subjects. Mitochondrial DNA/nuclear DNA in...

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PMID: 15814624
DOI: 10.1158/1078-0432.ccr-04-2147

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