Article
An oligonucleotide microarray for high-throughput sequencing of the mitochondrial genome.
The Journal of molecular diagnostics : JMD - 1 Sept 2006
Zhou Shaoyu, Kassauei Keyaunoosh, Cutler David J, Kennedy Giulia C, Sidransky David, Maitra Anirban, Califano Joseph
Abstract excerpt
Previously we developed an oligonucleotide sequencing microarray (MitoChip) as an array-based sequencing platform for rapid and high-throughput analysis of mitochondrial DNA. The first generation MitoChip, however, was not tiled with probes for the noncoding D-loop region, a site frequently mutated in human cancers. Here we report the development of a second-generation MitoChip (v2.0) with oligonucleotide probes...
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