Article
Morphology, distribution and phenotype of polycystin kidney disease 2-like 1-positive cerebrospinal fluid contacting neurons in the brainstem of adult mice.
PloS one - 1 Jan 2014
Orts-Del'Immagine Adeline, Kastner Anne, Tillement Vanessa, Tardivel Catherine, Trouslard Jérôme, Wanaverbecq Nicolas
Abstract excerpt
The mammalian spinal cord and medulla oblongata harbor unique neurons that remain in contact with the cerebrospinal fluid (CSF-cNs). These neurons were shown recently to express a polycystin member of the TRP channels family (PKD2L1) that potentially acts as a chemo- or mechanoreceptor. Recent studies carried out in young rodents indicate that spinal CSF-cNs express immature neuronal markers that appear to...
Topics
- Animals
- Axons
- Brain Stem
- Calcium Channels
- Cilia
- Dendrites
- Doublecortin Protein
- GABAergic Neurons
- Homeodomain Proteins
- Mice
- Mice, Transgenic