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Article

Association of TLR7 single nucleotide polymorphisms with chronic HCV-infection and response to interferon-a-based therapy.

Journal of viral hepatitis - 1 Jan 2008

Schott E, Witt H, Neumann K, Bergk A, Halangk J, Weich V, Müller T, Puhl G, Wiedenmann B, Berg T

Abstract excerpt

An efficient immune response against hepatitis C virus (HCV) is necessary to clear infection. As HCV is a single-stranded RNA virus, a role for TLR7 in the immune response against HCV is possible, and early clinical studies have demonstrated an antiviral effect of TLR7 stimulation. We tested the hypothesis that genetic variations of TLR7 are associated with chronic HCV-infection and outcome of therapy. The...

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Source

Identifiers

PMID: 18088248
DOI: 10.1111/j.1365-2893.2007.00898.x

Genes

TLR7

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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