Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A displaced PAG enhances proximal signaling and SDF-1-induced T cell migration.

European journal of immunology - 1 Jan 2008

Posevitz-Fejfár Anita, Smída Michal, Kliche Stefanie, Hartig Roland, Schraven Burkhart, Lindquist Jonathan A

Abstract excerpt

PAG, the phosphoprotein associated with glycosphingolipid-enriched microdomains (GEM), negatively regulates Src family kinases by recruiting C-terminal Src kinase (Csk) to the membrane, where Csk phosphorylates the inhibitory tyrosine of the Src kinases. S-acylation of a CxxC motif juxtaposed to the transmembrane domain within PAG has been proposed to be responsible for targeting PAG to the lipid rafts. Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Chemokine CXCL12

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoprecipitation

Share to Jurkat Cells

Share to Lymphocyte Activation

Share to Membrane Microdomains

Share to Receptors, Antigen, T-Cell

Share to T-Lymphocytes

Source

Identifiers

PMID: 18085663
DOI: 10.1002/eji.200636664

Genes

GEM
CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A displaced PAG enhances proximal signaling and SDF-1-induced T cell migration.PMID 18085663Read ↗

PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes.Semantic proximity Read ↗

PAG orchestrates T cell immune synapse function by binding to actinSemantic proximity Read ↗

A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development.Semantic proximity Read ↗

Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain.Semantic proximity Read ↗

The importance of claudin-7 palmitoylation on membrane subdomain localization and metastasis-promoting activities.Semantic proximity Read ↗

T cell activation induced by novel gain-of-function mutants of Syk and ZAP-70.Semantic proximity Read ↗

T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells.Semantic proximity Read ↗

EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration.Semantic proximity Read ↗

Palmitoylation at Cys595 is essential for PECAM-1 localisation into membrane microdomains and for efficient PECAM-1-mediated cytoprotection.Semantic proximity Read ↗

Plasma membrane and nuclear localization of G protein coupled receptor kinase 6A.Semantic proximity Read ↗

LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation.Semantic proximity Read ↗

The transmembrane domain of podoplanin is required for its association with lipid rafts and the induction of epithelial-mesenchymal transition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.