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Article

The transmembrane domain of podoplanin is required for its association with lipid rafts and the induction of epithelial-mesenchymal transition.

The international journal of biochemistry & cell biology - 1 Jun 2011

Fernández-Muñoz Beatriz, Yurrita María M, Martín-Villar Ester, Carrasco-Ramírez Patricia, Megías Diego, Renart Jaime, Quintanilla Miguel

Abstract excerpt

Podoplanin is a transmembrane glycoprotein that is upregulated in cancer and was reported to induce an epithelial-mesenchymal transition (EMT) in MDCK cells. The promotion of EMT was dependent on podoplanin binding to ERM (ezrin, radixin, moesin) proteins through its cytoplasmic (CT) domain, which led to RhoA-associated kinase (ROCK)-dependent ERM phosphorylation. Using detergent-resistant membrane (DRM) assays,...

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Amino Acid Motifs
Dogs
Epithelial-Mesenchymal Transition
Membrane Glycoproteins
Membrane Microdomains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Structure, Tertiary

Protein Transport

rho-Associated Kinases

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Identifiers

PMID: 21376833
DOI: 10.1016/j.biocel.2011.02.010

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