Article
T cell activation induced by novel gain-of-function mutants of Syk and ZAP-70.
The Journal of biological chemistry - 19 Jun 1998
Zeitlmann L, Knorr T, Knoll M, Romeo C, Sirim P, Kolanus W
Abstract excerpt
The Syk family tyrosine kinases play a crucial role in antigen receptor-mediated signal transduction, but their regulation and cellular targets remain incompletely defined. Following receptor engagement, phosphorylation of tyrosine residues within ZAP-70 and Syk is thought to control both kinase...
Topics
- Amino Acid Sequence
- Calcium
- Catalysis
- Enzyme Precursors
- Humans
- Interleukin-2
- Intracellular Signaling Peptides and Proteins
- Jurkat Cells
- Lymphocyte Activation
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Protein-Tyrosine Kinases
- Receptors, Antigen, B-Cell
- Receptors, Antigen, T-Cell
- Recombinant Fusion Proteins
- Signal Transduction
- Syk Kinase