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Article

T cell activation induced by novel gain-of-function mutants of Syk and ZAP-70.

The Journal of biological chemistry - 19 Jun 1998

Zeitlmann L, Knorr T, Knoll M, Romeo C, Sirim P, Kolanus W

Abstract excerpt

The Syk family tyrosine kinases play a crucial role in antigen receptor-mediated signal transduction, but their regulation and cellular targets remain incompletely defined. Following receptor engagement, phosphorylation of tyrosine residues within ZAP-70 and Syk is thought to control both kinase activity and recruitment of modulatory factors. We report here the characterization of novel mutants of ZAP-70 and Syk,...

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Identifiers

PMID: 9624129
DOI: 10.1074/jbc.273.25.15445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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T cell activation induced by novel gain-of-function mutants of Syk and ZAP-70.PMID 9624129Read ↗

Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck.Semantic proximity Read ↗

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Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70.Semantic proximity Read ↗

Development of SYK NanoBRET Cellular Target Engagement Assays for Gain–of–Function VariantsSemantic proximity Read ↗

Unperturbed Immune Function despite Mutation of C-Terminal Tyrosines in Syk Previously Implicated in Signaling and Activity Regulation.Semantic proximity Read ↗

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Generation of an analog-sensitive Syk tyrosine kinase for the study of signaling dynamics from the B cell antigen receptor.Semantic proximity Read ↗

PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes.Semantic proximity Read ↗

SYK expression endows human ZAP70-deficient CD8 T cells with residual TCR signaling.Semantic proximity Read ↗

Spleen Tyrosine Kinase (SYK) negatively regulates ITAM-mediated human NK cell signaling and CD19-CAR NK cell efficacySemantic proximity Read ↗

SRC homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) N-terminal tyrosine residues regulate a dynamic signaling equilibrium involving feedback of proximal T-cell receptor (TCR) signaling.Semantic proximity Read ↗

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