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Meiosis in oocytes: predisposition to aneuploidy and its increased incidence with age

14 Dec 2007

Abstract excerpt

Mammalian oocytes begin meiosis in the fetal ovary, but only complete it when fertilized in the adult reproductive tract. This review examines the cell biology of this protracted process: from entry of primordial germ cells into meiosis to conception. The defining feature of meiosis is two consecutive cell divisions (meiosis I and II) and two cell cycle arrests: at the germinal vesicle (GV), dictyate stage of...

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PMID: 18084010
DOI: 10.1093/humupd/dmm043

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