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Article

Parental age-related aneuploidy in human germ cells and offspring: A story of past and present

1 Jan 1996

Abstract excerpt

Parental age is the most important aetiological factor in trisomy formation in humans. Cytogenetic studies on germ cells reviewed here imply that (i) 2-4% sperm are aneuploid and 8.6% oocytes from IVF are hyperploid (ii) a paternal age effect may exist, and (iii) oocytes of aged women contain precociously separated chromatids in metaphase II. Trisomy data suggest that most aneuploidy is generated during meiosis I...

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Identifiers

PMID: 8908181
DOI: 10.1002/(sici)1098-2280(1996)28:3<211::aid-em6>3.0.co;2-g

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