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Meiotic Origins of Maternal Age-Related Aneuploidy1

29 Sept 2011

Abstract excerpt

Chromosome segregation errors in female meiosis lead to aneuploidy in the resulting egg and embryo, making them one of the leading genetic causes of spontaneous abortions and developmental disabilities in humans. It is known that aneuploidy of meiotic origin increases dramatically as women age, and current evidence suggests that most errors occur in meiosis I. Several hypotheses regarding the cause of maternal...

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PMID: 21957193
DOI: 10.1095/biolreprod.111.094367

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