Tn5 synaptic complex formation: role of transposase residue W450.

Abstract excerpt

A series of Tn5 transposases (Tnp's) with mutations at the conserved amino acid position W450, which was structurally predicted to be important for synapsis, have been generated and characterized. This study demonstrates that W450 is involved in hydrophobic (and possibly aromatic) contacts within the Tnp monomer that negatively regulate synaptic complex formation.

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to DNA Transposable Elements
• Share to Models, Biological
• Share to Models, Genetic