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Article

Structural basis of trans-synaptic interactions between PTPδ and SALMs for inducing synapse formation.

Nature communications - 18 Jan 2018

Goto-Ito Sakurako, Yamagata Atsushi, Sato Yusuke, Uemura Takeshi, Shiroshima Tomoko, Maeda Asami, Imai Ayako, Mori Hisashi, Yoshida Tomoyuki, Fukai Shuya

Abstract excerpt

Synapse formation is triggered by trans-synaptic interactions of cell adhesion molecules, termed synaptic organizers. Three members of type-II receptor protein tyrosine phosphatases (classified as type-IIa RPTPs; PTPδ, PTPσ and LAR) are known as presynaptic organizers. Synaptic adhesion-like molecules (SALMs) have recently emerged as a family of postsynaptic organizers. Although all five SALM isoforms can bind to...

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Share to Cell Adhesion Molecules, Neuronal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Isoforms

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Share to Receptor-Like Protein Tyrosine Phosphatases, Class 2

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Source

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Identifiers

PMID: 29348429
DOI: 10.1038/s41467-017-02417-z
PMCID: PMC5773591

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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