Article
Unlocking Tn3-family transposase activity in vitro unveils an asymetric pathway for transposome assembly.
Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 2017
Nicolas Emilien, Oger Cédric A, Nguyen Nathan, Lambin Michaël, Draime Amandine, Leterme Sébastien C, Chandler Michael, Hallet Bernard F J
Abstract excerpt
The Tn3 family is a widespread group of replicative transposons that are notorious for their contribution to the dissemination of antibiotic resistance and the emergence of multiresistant pathogens worldwide. The TnpA transposase of these elements catalyzes DNA breakage and rejoining reactions required for transposition. It also is responsible for target immunity, a phenomenon that prevents multiple insertions of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.