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Article

Inhibition of HIV-1 infection and replication by enhancing viral incorporation of innate anti-HIV-1 protein A3G: a non-pathogenic Nef mutant-based anti-HIV strategy.

The Journal of biological chemistry - 15 May 2009

Green Linden A, Liu Ying, He Johnny J

Abstract excerpt

APOBEC3G (A3G) is a cellular protein that has been identified as an innate anti-human immunodeficiency virus type 1 (HIV-1) factor. One of the major functions of HIV-1 virion infectivity protein (Vif) protein is to target A3G for ubiquitination/proteasome-mediated degradation and, as a result, evade the host innate defense mechanism. Thus, we wished to devise a strategy to restore the anti-HIV activity of A3G by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to nef Gene Products, Human Immunodeficiency Virus

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Share to vif Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 19324886
DOI: 10.1074/jbc.M806631200
PMCID: PMC2679436

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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