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Article

Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression.

The Journal of biological chemistry - 12 Sept 2008

Kubota Toru, Matsuoka Mayumi, Chang Tsung-Hsien, Tailor Prafullakumar, Sasaki Tsuguo, Tashiro Masato, Kato Atsushi, Ozato Keiko

Abstract excerpt

Viral infection activates Toll-like receptor and RIG-I (retinoic acid-inducible gene I) signaling pathways, leading to phosphorylation of IRF3 (interferon regulatory factor 3) and IRF7 and stimulation of type I interferon (IFN) transcription, a process important for innate immunity. We show that upon vesicular stomatitis virus infection, IRF3 and IRF7 are modified not only by phosphorylation but by the small...

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Identifiers

PMID: 18635538
DOI: 10.1074/jbc.M804479200
PMCID: PMC2533075

Genes

SUMO1
SUMO2
SUMO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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