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Article

Inhibition of Interferon Regulatory Factor 3 Activation by Paramyxovirus V Protein

26 Apr 2012

Abstract excerpt

The V protein of Sendai virus (SeV) suppresses innate immunity, resulting in enhancement of viral growth in mouse lungs and viral pathogenicity. The innate immunity restricted by the V protein is induced through activation of interferon regulatory factor 3 (IRF3). The V protein has been shown to interact with melanoma differentiation-associated gene 5 (MDA5) and to inhibit beta interferon production. In the...

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PMID: 22532687
DOI: 10.1128/jvi.06705-11

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