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Article

Innate Cellular Response to Virus Particle Entry Requires IRF3 but Not Virus Replication

27 Jan 2004

Abstract excerpt

Mammalian cells respond to virus infections by eliciting both innate and adaptive immune responses. One of the most effective innate antiviral responses is the production of alpha/beta interferon and the subsequent induction of interferon-stimulated genes (ISGs), whose products collectively limit virus replication and spread. Following viral infection, interferon is produced in a biphasic fashion that involves a...

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PMID: 14747536
DOI: 10.1128/jvi.78.4.1706-1717.2004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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