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Article

HIV-1 Vpu accessory protein induces caspase-mediated cleavage of IRF3 transcription factor.

The Journal of biological chemistry - 19 Dec 2014

Park Sang Yoon, Waheed Abdul A, Zhang Zai-Rong, Freed Eric O, Bonifacino Juan S

Abstract excerpt

Vpu is an accessory protein encoded by HIV-1 that interferes with multiple host-cell functions. Herein we report that expression of Vpu by transfection into 293T cells causes partial proteolytic cleavage of interferon regulatory factor 3 (IRF3), a key transcription factor in the innate anti-viral response. Vpu-induced IRF3 cleavage is mediated by caspases and occurs mainly at Asp-121. Cleavage produces a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to vif Gene Products, Human Immunodeficiency Virus

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Source

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Identifiers

PMID: 25352594
DOI: 10.1074/jbc.M114.597062
PMCID: PMC4271200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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