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Article

Caspase-8-mediated cleavage inhibits IRF-3 protein by facilitating its proteasome-mediated degradation.

The Journal of biological chemistry - 23 Sept 2011

Sears Nathaniel, Sen Ganes C, Stark George R, Chattopadhyay Saurabh

Abstract excerpt

Interferon regulatory factor 3 (IRF-3) plays a central role in inducing the expression of cellular antiviral genes, including the interferon-β gene, in response to Pattern Recognition Receptors. IRF-3 is targeted for proteasome-mediated degradation, which modulates the strength and duration of the innate immune responses that depend on it. We have found that caspase-8, which is activated by cytosolic...

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Identifiers

PMID: 21816816
DOI: 10.1074/jbc.M111.257022
PMCID: PMC3190878

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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