Article
Suggestive linkage of a chromosomal locus on 18p11 to cyclothymic temperament in bipolar disorder families.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Apr 2008
Evans Lynn M, Akiskal Hagop S, Greenwood Tiffany A, Nievergelt Caroline M, Keck Paul E, McElroy Susan L, Sadovnick A Dessa, Remick Ronald A, Schork Nicholas J, Kelsoe John R
Abstract excerpt
Attempts to identify bipolar disorder (BP) genes have only enjoyed limited success. One potential cause for this problem is that the traditional categorical BP phenotypes currently used in genetic linkage studies are not the most informative, efficient, or biologically relevant. An alternative to these strict categorical BP phenotypes is quantitative BP phenotypes. By isolating one aspect of a complex trait such...
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