Article
A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.
Translational psychiatry - 15 May 2012
Service S K, Verweij K J H, Lahti J, Congdon E, Ekelund J, Hintsanen M, Räikkönen K, Lehtimäki T, Kähönen M, Widen E, Taanila A, Veijola J, Heath A C, Madden P A F, Montgomery G W, Sabatti C, Järvelin M-R, Palotie A, Raitakari O, Viikari J, Martin N G, Eriksson J G, Keltikangas-Järvinen L, Wray N R, Freimer N B
Abstract excerpt
Temperament has a strongly heritable component, yet multiple independent genome-wide studies have failed to identify significant genetic associations. We have assembled the largest sample to date of persons with genome-wide genotype data, who have been assessed with Cloninger's Temperament and Character Inventory. Sum scores for novelty seeking, harm avoidance, reward dependence and persistence have been measured...
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