Article
Genome-wide linkage scan of 98 bipolar pedigrees and analysis of clinical covariates.
Molecular psychiatry - 1 Jul 2007
Zandi P P, Badner J A, Steele J, Willour V L, Miao K, MacKinnon D F, Mondimore F M, Schweizer B, McInnis M G, DePaulo J R, Gershon E, McMahon F J, Potash J B
Abstract excerpt
Despite compelling evidence that genetic factors contribute to bipolar disorder (BP), attempts to identify susceptibility genes have met with limited success. This may be due to the genetic heterogeneity of the disorder. We sought to identify susceptibility loci for BP in a genome-wide linkage scan with and without clinical covariates that might reflect the underlying heterogeneity of the disorder. We genotyped...
Topics
- Age of Onset
- Bipolar Disorder
- Chromosome Mapping
- Chromosomes, Human, Pair 2
- Chromosomes, Human, Pair 3
- Genetic Linkage
- Genetic Predisposition to Disease
- Humans
- Mood Disorders
- Pedigree