Article
Mutation of the HEXIM1 gene results in defects during heart and vascular development partly through downregulation of vascular endothelial growth factor.
Circulation research - 29 Feb 2008
Montano Monica M, Doughman Yong Qui, Deng Huayun, Chaplin Laura, Yang Jianqi, Wang Nancy, Zhou Qiang, Ward Nicole L, Watanabe Michiko
Abstract excerpt
Our previous studies and those of others indicated that the transcription factor Hexamethylene-bis-acetamide-inducible protein 1 (HEXIM1) is a tumor suppressor and cyclin-dependent kinase inhibitor, and that these HEXIM1 functions are mainly dependent on its C-terminal region. We provide evidence here that the HEXIM1 C-terminal region is critical for cardiovascular development. HEXIM1 protein was detected in the...
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