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Article

MDM2 Regulation of HIF Signaling Causes Microvascular Dysfunction in Hypertrophic Cardiomyopathy.

Circulation - 5 Dec 2023

Shridhar Puneeth, Glennon Michael S, Pal Soumojit, Waldron Christina J, Chetkof Ethan J, Basak Payel, Clavere Nicolas G, Banerjee Dipanjan, Gingras Sebastien, Becker Jason R

Abstract excerpt

BACKGROUND: Microvasculature dysfunction is a common finding in pathologic remodeling of the heart and is thought to play an important role in the pathogenesis of hypertrophic cardiomyopathy (HCM), a disease caused by sarcomere gene mutations. We hypothesized that microvascular dysfunction in HCM was secondary to abnormal microvascular growth and could occur independent of ventricular hypertrophy. METHODS: We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37886847
DOI: 10.1161/CIRCULATIONAHA.123.064332
PMCID: PMC10691664

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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