Article
Developmental ablation of Id1 and Id3 genes in the vasculature leads to postnatal cardiac phenotypes.
Developmental biology - 1 Jan 2011
Zhao Qingshi, Beck Amanda J, Vitale Joseph M, Schneider Joel S, Gao Shumin, Chang Corey, Elson Genie, Leibovich Samuel J, Park Ji Yeon, Tian Bin, Nam Hyung-song, Fraidenraich Diego
Abstract excerpt
The Id1 and Id3 genes play major roles during cardiac development, despite their expression being confined to non-myocardial layers (endocardium-endothelium-epicardium). We previously described that Id1Id3 double knockout (dKO) mouse embryos die at mid-gestation from multiple cardiac defects, but early lethality precluded the studies of the roles of Id in the postnatal heart. To elucidate postnatal roles of Id...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.