Article
Modulation of receptor phosphorylation contributes to activation of peroxisome proliferator activated receptor alpha by dehydroepiandrosterone and other peroxisome proliferators.
Molecular pharmacology - 1 Mar 2008
Tamasi Viola, Miller Kristy K Michael, Ripp Sharon L, Vila Ermin, Geoghagen Thomas E, Prough Russell A
Abstract excerpt
Dehydroepiandrosterone (DHEA), a C19 human adrenal steroid, activates peroxisome proliferator-activated receptor alpha (PPARalpha) in vivo but does not ligand-activate PPARalpha in transient transfection experiments. We demonstrate that DHEA regulates PPARalpha action by altering both the levels and phosphorylation status of the receptor. Human hepatoma cells (HepG2) were transiently transfected with the...
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