Article
Substitution of a conserved amino acid residue alters the ligand binding properties of peroxisome proliferator activated receptors.
FEBS letters - 17 Dec 1999
Causevic M, Wolf C R, Palmer C N
Abstract excerpt
Mutation of glutamic acid 282 of PPARalpha to glycine has been shown to result in an increased EC(50) for a wide variety of PPAR activating compounds. This has suggested that mutant receptor has a reduced ability to bind ligand. In this study we show that this mutation reduces the affinity of mPPARalpha and hPPARgamma for the fluorescent fatty acid, cis-parinaric acid and that the mutant hPPARgamma protein has a...
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