Article
A single amino acid change in the mouse peroxisome proliferator-activated receptor alpha alters transcriptional responses to peroxisome proliferators.
Molecular pharmacology - 1 Sept 1995
Hsu M H, Palmer C N, Griffin K J, Johnson E F
Abstract excerpt
The mouse peroxisome proliferator-activated receptor alpha (mP-PAR alpha) can activate transcription from the CYP4A6 promoter in transient cotransfection experiments in the absence (intrinsic transactivation) or presence of added peroxisome proliferator. However, mPPAR alpha-G, in which glycine i...
Topics
- Acyl-CoA Oxidase
- Animals
- Cell Line
- Cytochrome P-450 Enzyme System
- DNA
- Fatty Acids
- Haplorhini
- Humans
- Immunohistochemistry
- Isoenzymes
- Kidney
- Mice
- Microbodies
- Mutation
- Oxidoreductases
- Promoter Regions, Genetic
- Pyrimidines
- Rabbits