Glucocorticoids use a positive liver element to repress fibrate-induced adipose transcription of the phosphoenolpyruvate carboxykinase gene.

doi:10.1016/s0303-7207(96)04006-3

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Article

Glucocorticoids use a positive liver element to repress fibrate-induced adipose transcription of the phosphoenolpyruvate carboxykinase gene.

Molecular and cellular endocrinology - 28 Mar 1997

Franckhauser-Vogel S, Glorian M, Forest C

Abstract excerpt

Glucocorticoids inhibit basal and hormone-induced phosphoenolpyruvate carboxykinase (PEPCK) gene transcription in adipocytes whereas beta-adrenergic agonists and fibrates are stimulatory. Here we show that dexamethasone inhibits the induction of PEPCK mRNA by isoprenaline or clofibrate in 3T3-F44...

Topics

3T3 Cells
Adipocytes
Adrenergic beta-Agonists
Adrenergic beta-Antagonists
Animals
Cell Extracts
Clofibrate
DNA-Binding Proteins
Dexamethasone
Gene Expression Regulation, Enzymologic
Glucocorticoids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hypolipidemic Agents

Isoproterenol

Liver

Mice

Mifepristone

Mutation

Phosphoenolpyruvate Carboxykinase (GTP)

Source

Open in PubMed

Identifiers

PMID: 9099912
DOI: 10.1016/s0303-7207(96)04006-3

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9099912-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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