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Article

Differential regulation of human CYP4A genes by peroxisome proliferators and dexamethasone.

Archives of biochemistry and biophysics - 1 Jan 2003

Savas Uzen, Hsu Mei-Hui, Johnson Eric F

Abstract excerpt

HepG2 cells that stably overexpress PPARalpha were used to examine the regulation of the two known human CYP4A genes by Wy14643. Specific PCR amplification across intron 5 and restriction endonuclease analysis indicated that HepG2 cells possess genes corresponding to both the CYP4A11 cDNA and a more recently characterized gene, CYP4A22, that exhibits 95% identity to CYP4A11 in the coding region. These are...

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Share to Pyrimidines
Share to Anti-Inflammatory Agents, Non-Steroidal
Share to Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA, Complementary

Share to Gene Expression Regulation, Enzymologic

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Share to Mixed Function Oxygenases

Source

Identifiers

PMID: 12464261
DOI: 10.1016/s0003-9861(02)00499-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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