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Article

Transcriptional Regulation of the Human Sterol 12α-Hydroxylase Gene (CYP8B1)

1 Nov 2001

Abstract excerpt

Sterol 12α-hydroxylase catalyzes the synthesis of cholic acid and controls the ratio of cholic acid over chenodeoxycholic acid in the bile. Transcription of CYP8B1is inhibited by bile acids, cholesterol, and insulin. To study the mechanism of CYP8B1 transcription by bile acids, we have cloned and determined 3389 base pairs of the 5′-upstream nucleotide sequences of the human CYP8B1. Deletion analysis of...

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PMID: 11535594
DOI: 10.1074/jbc.m105117200

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