Article
Conservation and topology of protein interaction networks under duplication-divergence evolution.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 2008
Evlampiev Kirill, Isambert Hervé
Abstract excerpt
Genomic duplication-divergence processes are the primary source of new protein functions and thereby contribute to the evolutionary expansion of functional molecular networks. Yet, it is still unclear to what extent such duplication-divergence processes also restrict by construction the emerging properties of molecular networks, regardless of any specific cellular functions. We address this question, here,...
Topics
- Evolution, Molecular
- Gene Duplication
- Genetic Variation
- Metabolic Networks and Pathways
- Models, Genetic
- Models, Statistical
- Protein Interaction Domains and Motifs
- Proteins