Article
Natural selection on protein-coding genes in the human genome.
Nature - 20 Oct 2005
Bustamante Carlos D, Fledel-Alon Adi, Williamson Scott, Nielsen Rasmus, Hubisz Melissa Todd, Glanowski Stephen, Tanenbaum David M, White Thomas J, Sninsky John J, Hernandez Ryan D, Civello Daniel, Adams Mark D, Cargill Michele, Clark Andrew G
Abstract excerpt
Comparisons of DNA polymorphism within species to divergence between species enables the discovery of molecular adaptation in evolutionarily constrained genes as well as the differentiation of weak from strong purifying selection. The extent to which weak negative and positive darwinian selection have driven the molecular evolution of different species varies greatly, with some species, such as Drosophila...
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