Positive Selection and Centrality in the Yeast and Fly Protein-Protein Interaction Networks.

Abstract excerpt

Proteins within a molecular network are expected to be subject to different selective pressures depending on their relative hierarchical positions. However, it is not obvious what genes within a network should be more likely to evolve under positive selection. On one hand, only mutations at genes with a relatively high degree of control over adaptive phenotypes (such as those encoding highly connected proteins)...

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