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Article

Sequence-related human proteins cluster by degree of evolutionary conservation.

Physical review. E, Statistical, nonlinear, and soft matter physics - 1 Nov 2004

Mrowka Ralf, Patzak Andreas, Herzel Hanspeter, Holste Dirk

Abstract excerpt

Gene duplication followed by adaptive evolution is thought to be a central mechanism for the emergence of novel genes. To illuminate the contribution of duplicated protein-coding sequences to the complexity of the human genome, we study the connectivity of pairwise sequence-related human proteins and construct a network (N) of linked protein sequences with shared similarities. We find that (i) the connectivity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15600657
DOI: 10.1103/PhysRevE.70.051908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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