Article
The Arg389Gly β1-adrenoceptor gene polymorphism influences the acute effects of β-adrenoceptor blockade on contractility in the human heart.
Clinical research in cardiology : official journal of the German Cardiac Society - 1 Aug 2011
Huntgeburth Michael, La Rosée Karl, ten Freyhaus Henrik, Böhm Michael, Schnabel Petra, Hellmich Martin, Rosenkranz Stephan
Abstract excerpt
BACKGROUND: The β(1)-adrenoceptor (β(1)AR) mediates cardiostimulatory effects of catecholamines in the heart. The Arg389Gly polymorphism of the β(1)AR gene has recently been shown to determine the responsiveness to catecholamines in vitro, and we previously reported that dobutamine induced an augmented contractile response in humans homozygous for the Arg389 allele. The aim of the present study was to evaluate...
Topics
- Adrenergic beta-1 Receptor Antagonists
- Adult
- Arginine
- Echocardiography, Stress
- Genotype
- Glycine
- Humans
- Male
- Metoprolol
- Myocardial Contraction