Article
Beta1-adrenergic receptor polymorphisms and left ventricular remodeling changes in response to beta-blocker therapy.
Pharmacogenetics and genomics - 1 Apr 2005
Terra Steven G, Hamilton Karen K, Pauly Daniel F, Lee Craig R, Patterson J Herbert, Adams Kirkwood F, Schofield Richard S, Belgado Bernadette S, Hill James A, Aranda Juan M, Yarandi Hossein N, Johnson Julie A
Abstract excerpt
OBJECTIVE: Large variability exists in the improvement in left ventricular (LV) function from beta-blocker treatment. We hypothesized that polymorphisms at codon 389 (Arg389Gly) and 49 (Ser49Gly) in the beta1-adrenergic receptor (AR) gene were associated with LV reverse remodeling changes in resp...
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