Article
Effect of specific ADRB1/ADRB2/AGT genotype combinations on the association between survival and carvedilol treatment in chronic heart failure: a substudy of the ECHOS trial.
Pharmacogenetics and genomics - 1 Oct 2012
Petersen Morten, Andersen Jon T, Jimenez-Solem Espen, Broedbaek Kasper, Afzal Shoaib, Nyegaard Mette, Børglum Anders D, Stender Steen, Torp-Pedersen Christian, Køber Lars, Poulsen Henrik E
Abstract excerpt
OBJECTIVES: The aim of the present study was to determine whether carvedilol-treated chronic heart failure patients have a different prognosis when stratified for a specific combination of a gain-of-function genotype of the adrenergic β-1 receptor gene (ADRB1) (Arg389-homozygous), two gain-of-function genotypes of the angiotensinogen gene (AGT) (Thr174-homozygous and Thr235-homozygous), and a downregulated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.