Article
Synergistic polymorphisms of beta1 and alpha2C-adrenergic receptors and the influence on left ventricular ejection fraction response to beta-blocker therapy in heart failure.
Pharmacogenetics and genomics - 1 Apr 2007
Lobmeyer Maximilian T, Gong Yan, Terra Steven G, Beitelshees Amber L, Langaee Taimour Y, Pauly Daniel F, Schofield Richard S, Hamilton Karen K, Herbert Patterson J, Adams Kirkwood F, Hill James A, Aranda Juan M, Johnson Julie A
Abstract excerpt
OBJECTIVES: The Arg389Gly polymorphism (Arg389Gly) in the beta1-adrenergic receptor gene (ADRB1) has been associated with improvement in left-ventricular remodeling with beta-blocker treatment. One study of risk for heart failure suggested a synergistic effect of ADRB1 Arg389Gly with the insertion/deletion polymorphism in the alpha2C-adrenergic receptor gene (ADRA2C). We tested whether the ADRA2C...
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