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Article

Synthetic lethal interactions identify phenotypic "interologs" of the spindle assembly checkpoint components.

Genetics - 1 Dec 2007

Tarailo Maja, Tarailo Sanja, Rose Ann M

Abstract excerpt

Here, we report genetic interactions with mdf-1(gk2)/MAD1 in Caenorhabditis elegans. Nine are evolutionarily conserved or phenotypic "interologs" and two are novel enhancers, hcp-1 and bub-3. We show that HCP-1 and HCP-2, the two CENP-F-related proteins, recently implicated in the spindle assembly checkpoint (SAC) function, do not have identical functions, since hcp-1(RNAi), but not hcp-2(RNAi), enhances the...

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Identifiers

PMID: 18073444
DOI: 10.1534/genetics.107.080408
PMCID: PMC2219473

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Source receipt: pubmed, retrieved 7 Sept 2026.

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